Article
Influence of genetic polymorphisms on arsenic methylation efficiency during pregnancy: Evidence from a Spanish birth cohort.
The Science of the total environment - 20 Nov 2023
Soler-Blasco Raquel, Harari Florencia, Riutort-Mayol Gabriel, Murcia Mario, Lozano Manuel, Irizar Amaia, Marina Loreto Santa, Zubero Miren Begoña, Fernández-Jimenez Nora, Braeuer Simone, Ballester Ferran, Llop Sabrina
Abstract excerpt
BACKGROUND: Inorganic arsenic (iAs) is a widespread toxic metalloid. It is well-known that iAs metabolism and its toxicity are mediated by polymorphisms in AS3MT and other genes. However, studies during pregnancy are scarce. We aimed to examine the role of genetic polymorphisms in AS3MT, GSTO2, N6AMT1, MTHFR, MTR, FTCD, CBS, and FOLH1 in iAs methylation efficiency during pregnancy. METHODS: The study included 541...
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