Article
Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms.
International journal of molecular sciences - 1 Jan 2011
Agusa Tetsuro, Fujihara Junko, Takeshita Haruo, Iwata Hisato
Abstract excerpt
Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to trivalent arsenical, may play a role in arsenic metabolism in humans. Since the genetic polymorphisms of AS3MT gene may be associated with the susceptibility to inorganic arsenic...
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