Article
[Presence of mutations associated with ganciclovir resistance in cytomegalovirus UL97 gene].
Revista medica de Chile - 1 Apr 2010
Oyarzún María Angélica, Bustos Patricia, González Marcela, Domínguez María Isabel, Aguayo Francisco, Nervi Bruno, Ferres Marcela
Abstract excerpt
BACKGROUND: Long term use of ganciclovir (GCV) is associated with acquired resistance to it. Ninety percent of the responsible mutations occur in cytomegalovirus (CMV) UL 97 gene. AIM: To search for these mutations, comparing nucleotide sequences of CMV-positive samples from post transplant and immunocompromised patients receiving GCV, with sequences of CMV isolates obtained from subjects not exposed to the drug....
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