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Article

Incidence of cytomegalovirus UL97 and UL54 amino acid substitutions detected after 100 or 200 days of valganciclovir prophylaxis.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Mar 2012

Boivin Guy, Goyette Nathalie, Farhan Mahdi, Ives Jane, Elston Robert

Abstract excerpt

BACKGROUND: The IMPACT study was a randomized, double-blind study comparing 100 to 200 days of VGCV prophylaxis (900 mg once daily) in D+/R- kidney transplant recipients. Although extending the duration of prophylaxis resulted in a significant reduction in confirmed cytomegalovirus (CMV) disease (100-day: 36.8% vs 200-day: 16.1%(1)), the consequence of extending the duration of prophylaxis on the development of...

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PMID: 22237003
DOI: 10.1016/j.jcv.2011.12.019

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