Article
Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells.
PloS one - 26 Jul 2010
Franckhauser Celine, Mamaeva Daria, Heron-Milhavet Lisa, Fernandez Anne, Lamb Ned J C
Abstract excerpt
BACKGROUND: The dual specificity phosphatase cdc25C was the first human cdc25 family member found to be essential in the activation of cdk1/cyclin B1 that takes place at the entry into mitosis. Human cdc25C is phosphorylated on Proline-dependent SP and TP sites when it becomes active at mitosis and the prevalent model is that this phosphorylation/activation of cdc25C would be part of an amplification loop with...
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