Article
Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls.
Gynecologic oncology - 1 Oct 2012
Mingels Marjanka J J M, Roelofsen Thijs, van der Laak Jeroen A W M, de Hullu Joanne A, van Ham Maaike A P C, Massuger Leon F A G, Bulten Johan, Bol Mijke
Abstract excerpt
OBJECTIVE: A precursor lesion for ovarian carcinoma, tubal intraepithelial carcinoma (TIC), has been identified in BRCA-mutation carriers undergoing prophylactic bilateral salpingo-oophorectomy (pBSO). Other lesions were also identified in fallopian tubes, but different terminology, interpretation, and lack of knowledge of normal epithelium, have hampered to unravel their possible role in carcinogenesis. The aim...
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