Article
Ki-67 and p53 expression of the fallopian tube mucosa in breast cancer patients with hereditary risk.
Archives of gynecology and obstetrics - 1 May 2014
Anton Alina, Schott Sarah, Kaip Gisela, Rath Michelle, Heil Jörg, Aulmann Sebastian, Sinn Hans-Peter
Abstract excerpt
PURPOSE: The fallopian tube has been implicated as a site of origin of sporadic and BRCA1-related ovarian cancer. To investigate if Ki-67 or p53 is altered in BRCA1 mutation carriers, we have studied the expression of these markers in morphologically normal mucosa in the fallopian tube and fimbriae. METHODS: Prophylactic adnexectomy specimens from 24 patients (eight BRCA1 mutation carriers, eight non-mutation...
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