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Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors.

Archives of toxicology - 1 Aug 2020

Kasteel E E J, Darney K, Kramer N I, Dorne J L C M, Lautz L S

Abstract excerpt

UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isoforms (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7 and UGT2B15) and frequencies of human...

Topics

Biological Variation, Population
Genotype
Glucuronosyltransferase
Humans
Metabolic Detoxication, Phase II
Models, Statistical
Pharmacogenetics
Pharmacogenomic Variants
Phenotype
Substrate Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Toxicokinetics

Uncertainty

White People

Xenobiotics

Source

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Identifiers

PMID: 32415340
DOI: 10.1007/s00204-020-02765-8
PMCID: PMC7395075

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