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Article

Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity.

Rheumatology international - 1 Mar 2011

Rodríguez-Rodríguez Luis, Lamas José Ramón, Varadé Jezabel, López-Romero Pedro, Tornero-Esteban Pilar, Abasolo Lydia, de la Concha Emilio Gomez, Jover Juan Angel, Urcelay Elena, Fernández-Gutiérrez Benjamín

Abstract excerpt

Soluble interleukin-6 receptor α subunit (sIL-6R) is primarily generated by shedding of the membrane-bound form. This process is influenced by the single nucleotide polymorphism rs8192284 (A > C) resulting in an aspartic acid to alanine substitution (D358A) at the proteolytic cleavage site. The aim of this study was to determine whether plasma levels of sIL6R are influenced by the rs8192284 polymorphism in...

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Identifiers

PMID: 20661738
DOI: 10.1007/s00296-010-1593-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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