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Article

Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced.

Genes and immunity - 1 Sept 2004

Galicia J C, Tai H, Komatsu Y, Shimada Y, Akazawa K, Yoshie H

Abstract excerpt

We have investigated the association of the recently identified IL6R polymorphisms with the serum levels of soluble IL-6 receptor (sIL-6R). sIL-6R is generated by shedding of the membrane-bound receptor (IL-6Ralpha) or alternative mRNA splicing. In total, 115 healthy volunteers were genotyped, with 70 of them analyzed for sIL-6R levels. Using the PCR/RFLP methods, two important polymorphic sites were selected for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15306846
DOI: 10.1038/sj.gene.6364120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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