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Article

Solution structure and dynamics of the I214V mutant of the rabbit prion protein.

PloS one - 7 Oct 2010

Wen Yi, Li Jun, Xiong Minqian, Peng Yu, Yao Wenming, Hong Jing, Lin Donghai

Abstract excerpt

BACKGROUND: The conformational conversion of the host-derived cellular prion protein (PrP(C)) into the disease-associated scrapie isoform (PrP(Sc)) is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs). Various single-point mutations in PrP(C)s could cause structural changes and thereby distinctly influence the conformational conversion. Elucidation of the differences between the...

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Identifiers

PMID: 20949107
DOI: 10.1371/journal.pone.0013273
PMCID: PMC2951349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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