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Article

Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism.

The Biochemical journal - 1 Sept 2012

Biljan Ivana, Giachin Gabriele, Ilc Gregor, Zhukov Igor, Plavec Janez, Legname Giuseppe

Abstract excerpt

The most common form of prion disease in humans is sCJD (sporadic Creutzfeldt-Jakob disease). The naturally occurring E219K polymorphism in the HuPrP (human prion protein) is considered to protect against sCJD. To gain insight into the structural basis of its protective influence we have determined the NMR structure of recombinant HuPrP (residues 90-231) carrying the E219K polymorphism. The structure of the...

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PMID: 22676969
DOI: 10.1042/BJ20111940

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