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Article

A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise.

PloS one - 16 Jul 2010

Hamilton D Lee, Philp Andrew, MacKenzie Matthew G, Baar Keith

Abstract excerpt

BACKGROUND: Since activation of the PI3K/(protein kinase B; PKB/akt) pathway has been shown to alter muscle mass and growth, the aim of this study was to determine whether resistance exercise increased insulin like growth factor (IGF) I/phosphoinositide 3-kinase (PI3K) signalling and whether altering PI(3,4,5)P(3) metabolism genetically would increase load induced muscle growth. METHODOLOGY/PRINCIPAL FINDINGS:...

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Share to In Vitro Techniques
Share to Muscle, Skeletal
Share to Myocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositols

Share to PTEN Phosphohydrolase

Share to Receptor, IGF Type 1

Share to Ribosomal Protein S6 Kinases, 90-kDa

Share to Stress, Mechanical

Source

Open in PubMed Open full text

Identifiers

PMID: 20661274
DOI: 10.1371/journal.pone.0011624
PMCID: PMC2905373

Genes

PTEN
PLN
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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