Article
The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth.
The Journal of physiology - 15 Nov 2011
Goodman Craig A, Frey John W, Mabrey Danielle M, Jacobs Brittany L, Lincoln Hannah C, You Jae-Sung, Hornberger Troy A
Abstract excerpt
Chronic mechanical loading (CML) of skeletal muscle induces compensatory growth and the drug rapamycin has been reported to block this effect. Since rapamycin is considered to be a highly specific inhibitor of the mammalian target of rapamycin (mTOR), many have concluded that mTOR plays a key role in CML-induced growth regulatory events. However, rapamycin can exert mTOR-independent actions and systemic...
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