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Article

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.

The Journal of biological chemistry - 3 Apr 2009

Ning Ke, Miller Lisa C, Laidlaw Hilary A, Watterson Kenneth R, Gallagher Jennifer, Sutherland Calum, Ashford Michael L J

Abstract excerpt

Leptin activates multiple signaling pathways in cells, including the phosphatidylinositol 3-kinase pathway, indicating a degree of cross-talk with insulin signaling. The exact mechanisms by which leptin alters this signaling pathway and how it relates to functional outputs are unclear at present. A previous study has established that leptin inhibits the activity of the phosphatase PTEN (phosphatase and tensin...

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Source

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Identifiers

PMID: 19208634
DOI: 10.1074/jbc.M806774200
PMCID: PMC2666585

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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