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Article

Genetic link between obesity and MMP14-dependent adipogenic collagen turnover.

Diabetes - 1 Oct 2010

Chun Tae-Hwa, Inoue Mayumi, Morisaki Hiroko, Yamanaka Itaru, Miyamoto Yoshihiro, Okamura Tomonori, Sato-Kusubata Kaori, Weiss Stephen J

Abstract excerpt

OBJECTIVE: In white adipose tissue, adipocytes and adipocyte precursor cells are enmeshed in a dense network of type I collagen fibrils. The fate of this pericellular collagenous web in diet-induced obesity, however, is unknown. This study seeks to identify the genetic underpinnings of proteolytic collagen turnover and their association with obesity progression in mice and humans. RESEARCH DESIGN AND METHODS: The...

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Topics

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Share to Adipose Tissue
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dietary Fats

Share to Gene Expression Regulation, Enzymologic

Share to Matrix Metalloproteinase 14

Share to Obesity

Share to Oligonucleotide Array Sequence Analysis

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 20660624
DOI: 10.2337/db10-0073
PMCID: PMC3279534

Genes

MMP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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