Article
Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.
Circulation research - 3 Jul 2015
Martín-Alonso Mara, García-Redondo Ana B, Guo Dongchuan, Camafeita Emilio, Martínez Fernando, Alfranca Arántzazu, Méndez-Barbero Nerea, Pollán Ángela, Sánchez-Camacho Cristina, Denhardt David T, Seiki Motoharu, Vázquez Jesús, Salaices Mercedes, Redondo Juan Miguel, Milewicz Dianna, Arroyo Alicia G
Abstract excerpt
RATIONALE: Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations in genes that affect vascular smooth muscle cell differentiation and contractility or extracellular matrix composition and assembly. However, as many as 75% of patients with a family history of aortic aneurysms do not have an identified genetic syndrome....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.