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Article

Exploring the impact of collagen-I genetic variants on intestinal structure and gut microbiota in mouse models of osteogenesis imperfecta.

Scientific reports - 6 Apr 2026

Zhang Yuan K, Iskandar Michèle M, Kubow Stan, Komarova Svetlana V, Tauer Josephine T

Abstract excerpt

Osteogenesis imperfecta (OI), an inherited connective tissue disorder, primarily results from genetic variants that alter collagen-I. Collagen-I also plays a crucial role in intestinal structure and function. A recent large cohort reported an increased risk of gastrointestinal diseases in OI patients, including peptic ulcer disease, inflammatory bowel disease, and constipation. However, the extent of intestinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41942702
DOI: 10.1038/s41598-026-47221-2
PMCID: PMC13234298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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