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Article

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin.

The Journal of investigative dermatology - 1 Aug 2016

Zigrino Paola, Brinckmann Jürgen, Niehoff Anja, Lu Yinhui, Giebeler Nives, Eckes Beate, Kadler Karl E, Mauch Cornelia

Abstract excerpt

Proteolytic activities in the extracellular matrix by the matrix metalloproteinase (MMP)-14 have been implicated in the remodeling of collagenous proteins during development. To analyze the function of fibroblast-derived MMP-14 in adult skin homeostasis, we generated mice with inducible deletion of MMP-14 in the dermal fibroblast (MMP-14(Sf-/-)). These mice are smaller and display a fibrosis-like phenotype in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27066886
DOI: 10.1016/j.jid.2016.03.036
PMCID: PMC4946792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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