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Article

Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development

17 Apr 2007

Abstract excerpt

Recessive inactivating mutations in human matrix metalloproteinase 2 (MMP2, gelatinase A) are associated with syndromes that include abnormal facial appearance, short stature, and severe bone loss. Mmp2(-/-) mice have only mild aspects of these abnormalities, suggesting that MMP2 function is redundant during skeletal development in the mouse. Here, we report that Mmp2(-/-) mice with additional mutations that...

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PMID: 17440987
DOI: 10.1002/dvdy.21159

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