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Article

Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

PloS one - 1 Jan 2013

Imai Takahiko, Koyanagi Naoto, Ogawa Ryo, Shindo Keiko, Suenaga Tadahiro, Sato Ayuko, Arii Jun, Kato Akihisa, Kiyono Hiroshi, Arase Hisashi, Kawaguchi Yasushi

Abstract excerpt

Detection and elimination of virus-infected cells by CD8(+) cytotoxic T lymphocytes (CTLs) depends on recognition of virus-derived peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of infected cells. In the present study, we showed that inactivation of the activity of viral kinase Us3 encoded by herpes simplex virus 1 (HSV-1), the etiologic agent of several human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23951282
DOI: 10.1371/journal.pone.0072050
PMCID: PMC3741198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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