Article
Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2000
Murata T, Goshima F, Daikoku T, Takakuwa H, Nishiyama Y
Abstract excerpt
BACKGROUND: Although the US3 gene product of herpes simplex virus (HSV) has been identified as a serine/threonine protein kinase (PK), the functions are poorly understood. RESULTS: We found that US3 PK of HSV-2 induced disruption of actin filaments, cell rounding and accumulation of binucleate cells in HEp2 cells. Cell rounding was abrogated by expression of either kinase-dead forms of US3 PK or a mutant protein...
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