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Article

VEGF-A loss in the haematopoietic and endothelial lineages exacerbates age-induced renal changes.

Microvascular research - 1 Dec 2010

Yamaji Maiko, Bielby Holli, Licence Di, Cheng Ching-wen, Cook Emma, Smith Stephen K, Print Cristin G, Charnock-Jones D Stephen

Abstract excerpt

Renal function declines with age and this is more pronounced in males than females. VEGF-A is essential for glomerular development and function but its role in other aspects of renal function is poorly understood. We therefore investigated the role of VEGF-A, derived specifically from haematopoietic and endothelial lineages in the kidney. We crossed VavCre and floxed Vegf-a mice allowing specific ablation of a...

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Identifiers

PMID: 20659482
DOI: 10.1016/j.mvr.2010.07.006

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