Article
Glomerular and renal vascular structural changes in alpha8 integrin-deficient mice.
Journal of the American Society of Nephrology : JASN - 1 Sept 2003
Haas Christian S, Amann Kerstin, Schittny Johannes, Blaser Barbara, Müller Ulrich, Hartner Andrea
Abstract excerpt
Integrins are matrix receptors that regulate cell-matrix interactions during development and in adult tissue. In the adult kidney, the alpha8 chain is specifically expressed in glomerular mesangial cells and vascular smooth muscle cells. alpha8-deficient (alpha8-/-) mice demonstrate reductions in...
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