Article
Aspects of the renal phenotype of adult alpha8 integrin-deficient mice.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jan 2002
Hartner Andrea, Haas Christian, Amann Kerstin, Sterzel R Bernd
Abstract excerpt
Integrins mediate cell-matrix interactions which are important for organ development. In the kidney, alpha8 integrin is expressed during early nephrogenesis. In alpha8 gene-mutated mice, lack of alpha8 leads to unilateral or bilateral renal agenesis in part of the animals. We investigated surviving animals with one or two kidneys. These mice had significantly reduced renal mass and displayed higher blood pressure...
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