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Article

Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2008

Zhang Wenjing, Ito Hironori, Quint Marcel, Huang He, Noël Laurent D, Gray William M

Abstract excerpt

SKP1-Cullin1-F-box protein (SCF) ubiquitin-ligases regulate numerous aspects of eukaryotic growth and development. Cullin-Associated and Neddylation-Dissociated (CAND1) modulates SCF function through its interactions with the CUL1 subunit. Although biochemical studies with human CAND1 suggested that CAND1 plays a negative regulatory role by sequestering CUL1 and preventing SCF complex assembly, genetic studies in...

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Source

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Identifiers

PMID: 18550827
DOI: 10.1073/pnas.0804144105
PMCID: PMC2448860

Genes

CAND1
CUL1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.PMID 18550827Read ↗

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