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Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury.

Molecular neurobiology - 1 Nov 2020

Ahmed Mohammad Ejaz, Selvakumar Govindhasamy Pushpavathi, Kempuraj Duraisamy, Raikwar Sudhanshu P, Thangavel Ramasamy, Bazley Kieran, Wu Kristopher, Khan Osaid, Khan Asher, Zaheer Smita, Iyer Shankar, Burton Casey, James Donald, Zaheer Asgar

Abstract excerpt

Traumatic brain injury (TBI) induces inflammatory responses through microglial activation and polarization towards a more inflammatory state that contributes to the deleterious secondary brain injury. Glia maturation factor (GMF) is a pro-inflammatory protein that is responsible for neuroinflammation following insult to the brain, such as in TBI. We hypothesized that the absence of GMF in GMF-knockout (GMF-KO)...

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PMID: 32737763
DOI: 10.1007/s12035-020-02040-y

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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