Article
H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO.
Molecular microbiology - 1 Sept 2010
Westra Edze R, Pul Umit, Heidrich Nadja, Jore Matthijs M, Lundgren Magnus, Stratmann Thomas, Wurm Reinhild, Raine Amanda, Mescher Melina, Van Heereveld Luc, Mastop Marieke, Wagner E Gerhart H, Schnetz Karin, Van Der Oost John, Wagner Rolf, Brouns Stan J J
Abstract excerpt
The recently discovered prokaryotic CRISPR/Cas defence system provides immunity against viral infections and plasmid conjugation. It has been demonstrated that in Escherichia coli transcription of the Cascade genes (casABCDE) and to some extent the CRISPR array is repressed by heat-stable nucleoid-structuring (H-NS) protein, a global transcriptional repressor. Here we elaborate on the control of the E. coli...
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