Article
The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli.
PloS one - 1 Jan 2012
Yun Sang Hoon, Ji Sang Chun, Jeon Heung Jin, Wang Xun, Kim Si Wouk, Bak Geunu, Lee Younghoon, Lim Heon M
Abstract excerpt
Cnu (an OriC-binding nucleoid protein) associates with H-NS. A variant of Cnu was identified as a key factor for filamentous growth of a wild-type Escherichia coli strain at 37°C. This variant (CnuK9E) bears a substitution of a lysine to glutamic acid, causing a charge reversal in the first helix. The temperature-dependent filamentous growth of E. coli bearing CnuK9E could be reversed by either lowering the...
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