Article
Evidence for lateral mobility of voltage sensors in prokaryotic voltage-gated sodium channels.
Biochemical and biophysical research communications - 27 Aug 2010
Nagura Hitoshi, Irie Katsumasa, Imai Tomoya, Shimomura Takushi, Hige Toshihide, Fujiyoshi Yoshinori
Abstract excerpt
Voltage-sensor domains (VSDs) in voltage-gated ion channels are thought to regulate the probability that a channel adopts an open conformation by moving vertically in the lipid bilayer. Here we characterized the movement of the VSDs of the prokaryotic voltage-gated sodium channel, NaChBac. Substitution of residue T110, which is located on the extracellular side of the fourth transmembrane helix of the VSD, by...
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