Article
New insights into the troubles of aneuploidy.
Annual review of cell and developmental biology - 1 Jan 2012
Siegel Jake J, Amon Angelika
Abstract excerpt
Deviation from a balanced genome by either gain or loss of entire chromosomes is generally tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell division lead to aneuploidy, which places a burden of additional or insufficient gene products from the missegregated chromosomes on the daughter cells. The burden of aneuploidy often manifests itself as impaired fitness of...
Topics
- Abnormal Karyotype
- Adaptation, Biological
- Aneuploidy
- Animals
- Chromosome Segregation
- Gene Dosage
- Gene Expression
- Humans
- Mitosis
- Neoplasms
- Neurodegenerative Diseases
- Phenotype