Article
High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density.
Bone - 1 Nov 2010
Giroux Sylvie, Elfassihi Latifa, Clément Valérie, Bussières Johanne, Bureau Alexandre, Cole David E C, Rousseau François
Abstract excerpt
Osteoporosis is a bone disease characterized by low bone mineral density (BMD), a highly heritable and polygenic trait. Women are more prone than men to develop osteoporosis due to a lower peak bone mass and accelerated bone loss at menopause. Peak bone mass has been convincingly shown to be due to genetic factors with heritability up to 80%. Menopausal bone loss has been shown to have around 38% to 49%...
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