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Article

Association of INSIG2 polymorphism with overweight and LDL in children.

PloS one - 1 Jan 2015

Kaulfers Anne-Marie, Deka Ranjan, Dolan Lawrence, Martin Lisa J

Abstract excerpt

BACKGROUND: Dyslipidemia and overweight are common issues in children. Identifying genetic markers of risk could lead to targeted interventions. A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis. OBJECTIVE: To identify polymorphisms in INSIG2 which are associated with overweight (BMI ≥...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25607990
DOI: 10.1371/journal.pone.0116340
PMCID: PMC4301876

Genes

INSIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Association of INSIG2 polymorphism with overweight and LDL in children.PMID 25607990Read ↗

[Association of abnormal lipid metabolism with INSIG2 gene variant in overweight and obese children].Semantic proximity Read ↗

Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.Semantic proximity Read ↗

Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.Semantic proximity Read ↗

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.Semantic proximity Read ↗

A common genetic variant is associated with adult and childhood obesity.Semantic proximity Read ↗

Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).Semantic proximity Read ↗

INSIG1 influences obesity-related hypertriglyceridemia in humans.Semantic proximity Read ↗

Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China.Semantic proximity Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.Semantic proximity Read ↗

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