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Article

Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.

Human molecular genetics - 20 Dec 2013

Regal Joshua A, Festerling Todd A, Buis Jeffrey M, Ferguson David O

Abstract excerpt

DNA double-strand breaks (DSBs) can lead to instability of the genome if not repaired correctly. The MRE11/RAD50/NBS1 (MRN) complex binds DSBs and initiates damage-induced signaling cascades via activation of the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia- and rad3-related (ATR) kinases. Mutations throughout MRE11 cause ataxia-telangiectasia-like disorder (ATLD) featuring cerebellar...

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Share to Ataxia Telangiectasia
Share to DNA-Binding Proteins
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23912341
DOI: 10.1093/hmg/ddt368
PMCID: PMC3842175

Genes

MRE11
ATM
ATR
RAD50

Provenance

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