APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.

doi:10.1681/ASN.2011040388

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Article

APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Nov 2011

Kopp Jeffrey B, Nelson George W, Sampath Karmini, Johnson Randall C, Genovese Giulio, An Ping, Friedman David, Briggs William, Dart Richard, Korbet Stephen, Mokrzycki Michele H, Kimmel Paul L, Limou Sophie, Ahuja Tejinder S, Berns Jeffrey S, Fryc Justyna, Simon Eric E, Smith Michael C, Trachtman Howard, Michel Donna M, Schelling Jeffrey R, Vlahov David, Pollak Martin, Winkler Cheryl A

Abstract excerpt

Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271 African American cases, 168 European American cases, and 939 control subjects. In a recessive model, APOL1 variants conferred seventeenfold higher odds (95% CI 11...

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Identifiers

PMID: 21997394
DOI: 10.1681/ASN.2011040388
PMCID: PMC3231787

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APOL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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