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Article

Study of transcriptional effects in Cis at the IFIH1 locus.

PloS one - 13 Jul 2010

Zouk Hana, Marchand Luc, Polychronakos Constantin

Abstract excerpt

BACKGROUND: The Thr allele at the non-synonymous single-nucleotide polymorphism (nsSNP) Thr946Ala in the IFIH1 gene confers risk for Type 1 diabetes (T1D). The SNP is embedded in a 236 kb linkage disequilibrium (LD) block that includes four genes: IFIH1, GCA, FAP and KCNH7. The absence of common nsSNPs in the other genes makes the IFIH1 SNP the strongest functional candidate, but it could be merely a marker of...

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Share to Diabetes Mellitus, Type 1
Share to Cell Line
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-Induced Helicase, IFIH1

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 20644636
DOI: 10.1371/journal.pone.0011564
PMCID: PMC2903489

Genes

IFIH1
FAP
GCA
KCNH7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Study of transcriptional effects in Cis at the IFIH1 locus.PMID 20644636Read ↗

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The IFIH1-A946T risk variant promotes diabetes in a sex-dependent mannerSemantic proximity Read ↗

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The association between the IFIH1 locus and type 1 diabetes.Semantic proximity Read ↗

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells.Semantic proximity Read ↗

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The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.Semantic proximity Read ↗

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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.Semantic proximity Read ↗

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