Article

Transcription factors SP5 and SP8 drive primary cilia formation

2025-06-03

Abstract excerpt

While specific transcription factors are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multi-omics comparison of the transcriptomes of ciliated and non-ciliated embryonic cells to identify transcription factors upregulated in ciliated cells, and conditional genetics in mouse embryos and stem cells to demonstrate that SP5...

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Literature Corpus work: 47667b46-a4a8-535d-b56b-819d4bc1a3af
DOI: 10.1101/2025.06.03.657415

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