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Article

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.

Nature cell biology - 1 Jan 2006

Hamaratoglu Fisun, Willecke Maria, Kango-Singh Madhuri, Nolo Riitta, Hyun Eric, Tao Chunyao, Jafar-Nejad Hamed, Halder Georg

Abstract excerpt

Merlin, the protein product of the Neurofibromatosis type-2 gene, acts as a tumour suppressor in mice and humans. Merlin is an adaptor protein with a FERM domain and it is thought to transduce a growth-regulatory signal. However, the pathway through which Merlin acts as a tumour suppressor is poorly understood. Merlin, and its function as a negative regulator of growth, is conserved in Drosophila, where it...

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PMID: 16341207
DOI: 10.1038/ncb1339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.PMID 16341207Read ↗

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.Semantic proximity Read ↗

Merlin regulates signaling events at the nexus of development and cancerSemantic proximity Read ↗

The molecular biology of NF2/Merlin on tumorigenesis and development.Semantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling.Semantic proximity Read ↗

Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation.Semantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

Conformational flexibility determines the Nf2/merlin tumor suppressor functionsSemantic proximity Read ↗

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.Semantic proximity Read ↗

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.Semantic proximity Read ↗

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