Article
Molecular alterations of the NF2 gene in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Oncology reports - 1 Dec 2017
Zhang Ning, Zhao Zhang, Long Jiang, Li Hai, Zhang Bei, Chen Guangyong, Li Xiaojin, Lv Tingxia, Zhang Wei, Ou Xiaojuan, Xu Anjian, Huang Jian
Abstract excerpt
Neurofibromatosis type 2 with mutations in the neurofibromin 2 (NF2) gene, encoding the Merlin protein, is an autosomal dominant disorder characterized by enhanced cancer predisposition, particularly tumors of the central nervous system. Recent animal studies indicate that disruption of NF2/Merlin function in oval cells, which are hepatic progenitor cells, may lead to the development of primary liver cancers...
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