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Article

Genetic bottlenecks and the hazardous game of population reduction in cell line based research.

Experimental cell research - 10 Dec 2010

Gisselsson David, Lindgren David, Mengelbier Linda Holmquist, Øra Ingrid, Yeger Herman

Abstract excerpt

Established tumour cell lines are ubiquitous tools in research, but their representativity is often debated. One possible caveat is that many cell lines are derived from cells with genomic instability, potentially leading to genotype changes in vitro. We applied SNP-array analysis to an established tumour cell line (WiT49). Even though WiT49 exhibited chromosome segregation errors in 30% of cell divisions, only a...

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Identifiers

PMID: 20643124
DOI: 10.1016/j.yexcr.2010.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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