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Article

Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays.

Nucleic acids research - 1 Aug 2009

Geigl Jochen B, Obenauf Anna C, Waldispuehl-Geigl Julie, Hoffmann Eva M, Auer Martina, Hörmann Martina, Fischer Maria, Trajanoski Zlatko, Schenk Michael A, Baumbusch Lars O, Speicher Michael R

Abstract excerpt

Clinical DNA is often available in limited quantities requiring whole-genome amplification for subsequent genome-wide assessment of copy-number variation (CNV) by array-CGH. In pre-implantation diagnosis and analysis of micrometastases, even merely single cells are available for analysis. However, procedures allowing high-resolution analyses of CNVs from single cells well below resolution limits of conventional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19541849
DOI: 10.1093/nar/gkp526
PMCID: PMC2731907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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