Article
The mid p-value in exact tests for Hardy-Weinberg equilibrium.
Statistical applications in genetics and molecular biology - 1 Aug 2013
Graffelman Jan, Moreno Victor
Abstract excerpt
OBJECTIVE: Exact tests for Hardy-Weinberg equilibrium are widely used in genetic association studies. We evaluate the mid p-value, unknown in the genetics literature, as an alternative for the standard p-value in the exact test. METHOD: The type 1 error rate and the power of the exact test are calculated for different sample sizes, significance levels, minor allele counts and degrees of deviation from...
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