Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers

14 Apr 2010

Abstract excerpt

OBJECTIVE: Recent evidence suggests that high molecular weight soluble oligomeric Abeta (oAbeta) assemblies (also known as Abeta-derived diffusible ligands, or ADDLs) may represent a primary neurotoxic basis for cognitive failure in Alzheimer disease (AD). To date, most in vivo studies of oAbeta/ADDLs have involved injection of assemblies purified from the cerebrospinal fluid of human subjects with AD or from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Dementia and Cognitive Impairment Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20641005
DOI: 10.1002/ana.22052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomersPMID 20641005Read ↗

Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model.Semantic proximity Read ↗

Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains.Semantic proximity Read ↗

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.Semantic proximity Read ↗

Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's disease model.Semantic proximity Read ↗

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 MiceSemantic proximity Read ↗

A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Validation of a 2-day water maze protocol in mice.Semantic proximity Read ↗

Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model.Semantic proximity Read ↗

Treatment with an Amyloid-β Antibody Ameliorates Plaque Load, Learning Deficits, and Hippocampal Long-Term Potentiation in a Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Motor activity in young APPswe + PS1/A246E bigenic mice as a predicting variable for memory decline.Semantic proximity Read ↗

Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Inhaled Anesthetic Potency in Aged Alzheimer MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.