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Article

Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's disease.

Current Alzheimer research - 1 Jan 2015

Schrott L M, Jackson K, Yi P, Dietz F, Johnson G S, Basting T F, Purdum G, Tyler T, Rios J D, Castor T P, Alexander J S

Abstract excerpt

BACKGROUND: Previous studies showed that Bryostatin-1, a potent PKC modulator and alphasecretase activator, can improve cognition in models of Alzheimer's disease (AD) with chronic (>10 weeks), intraperitoneal (i.p.) administration of the drug. We compared learning and spatial memory in the APPswe, PSEN1dE985Dbo (APP/PS1) mouse model of AD and studied the ability of acute intraperitoneal and oral Bryostatin-1 to...

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Source

Identifiers

PMID: 25523423
DOI: 10.2174/1567205012666141218141904

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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