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Article

Predictive models for population performance on real biological fitness landscapes.

Bioinformatics (Oxford, England) - 1 Sept 2010

Rowe William, Wedge David C, Platt Mark, Kell Douglas B, Knowles Joshua

Abstract excerpt

MOTIVATION: Directed evolution, in addition to its principal application of obtaining novel biomolecules, offers significant potential as a vehicle for obtaining useful information about the topologies of biomolecular fitness landscapes. In this article, we make use of a special type of model of fitness landscapes-based on finite state machines-which can be inferred from directed evolution experiments....

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Identifiers

PMID: 20639542
DOI: 10.1093/bioinformatics/btq353

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