Article
Empirical fitness landscapes and the predictability of evolution.
Nature reviews. Genetics - 1 Jul 2014
de Visser J Arjan G M, Krug Joachim
Abstract excerpt
The genotype-fitness map (that is, the fitness landscape) is a key determinant of evolution, yet it has mostly been used as a superficial metaphor because we know little about its structure. This is now changing, as real fitness landscapes are being analysed by constructing genotypes with all possible combinations of small sets of mutations observed in phylogenies or in evolution experiments. In turn, these first...
Topics
- Adaptation, Biological
- Anti-Bacterial Agents
- Aspergillus niger
- Biological Evolution
- Computer Simulation
- Drug Resistance, Microbial
- Escherichia coli
- Genetic Fitness
- Genotype
- Methylobacterium extorquens
- Models, Genetic