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Article

Sequence-free landscape inference for directed evolution.

PLoS computational biology - 1 Sept 2026

Towers Sebastian, James Jessica, Steel Harrison, Kempf Idris

Abstract excerpt

Directed evolution is a method for engineering biological systems or components, such as proteins, wherein desired traits are optimised through iterative rounds of mutagenesis and selection of fit variants. The process of protein directed evolution can be envisaged as navigation over high-dimensional optimisation landscapes with numerous local maxima. The performance of any strategy in navigating such a landscape...

Read the complete abstract on PubMed

Topics

Directed Molecular Evolution
Computational Biology
Proteins
Models, Genetic
Mutation
Evolution, Molecular
Computer Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Algorithms

Protein Engineering

Mutation Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 42691096
DOI: 10.1371/journal.pcbi.1014713
PMCID: PMC13585340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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