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Article

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010

Nishimura Akiyuki, Kitano Ken, Takasaki Jun, Taniguchi Masatoshi, Mizuno Norikazu, Tago Kenji, Hakoshima Toshio, Itoh Hiroshi

Abstract excerpt

Heterotrimeric GTP-binding proteins (G proteins) transmit extracellular stimuli perceived by G protein-coupled receptors (GPCRs) to intracellular signaling cascades. Hundreds of GPCRs exist in humans and are the targets of a large percentage of the pharmaceutical drugs used today. Because G proteins are regulated by GPCRs, small molecules that directly modulate G proteins have the potential to become therapeutic...

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Share to Crystallography, X-Ray
Share to GTP-Binding Protein alpha Subunits, Gq-G11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrophobic and Hydrophilic Interactions

Share to Models, Molecular

Share to Peptides, Cyclic

Share to Protein Structure, Quaternary

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Source

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Identifiers

PMID: 20639466
DOI: 10.1073/pnas.1003553107
PMCID: PMC2922266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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