Article
CD3 deficiencies.
Current opinion in allergy and clinical immunology - 1 Dec 2005
Fischer Alain, de Saint Basile Geneviève, Le Deist Françoise
Abstract excerpt
PURPOSE OF REVIEW: The molecular characterization of inherited T-cell immunodeficiencies has contributed to delineating key factors in human T-cell development. This review reports on the recent description of deleterious mutations in the genes encoding CD3 subunits expressed at the T-lymphocyte membrane in association with the T-cell receptor. RECENT FINDINGS: Homozygous mutations in CD3D and CD3E genes lead to...
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