Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Redox regulation of the tumor suppressor PTEN by glutathione.

FEBS letters - 20 Aug 2010

Kim Yujeong, Song Yong Bhum, Kim Tae-Youl, Kim Inyoung, Han Seong-Jeong, Ahn Younghee, Cho Seung-Hyun, Choi Cheol Yong, Chay Kee-Oh, Yang Sung Yeul, Ahn Bong Whan, Huh Won-Ki, Lee Seung-Rock

Abstract excerpt

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expressed in Saccharomyces cerevisiae was reversibly oxidized by hydrogen peroxide and reduced by cellular reductants. Reduction of hPTEN was delayed in each of S. cerevisiae gsh1Delta and gsh2Delta mutants. Expression of gamma-glutamylcysteine synthetase Gsh1 in the gsh1Delta mutant rescued regeneration rate of hPTEN. Oxidized hPTEN was reduced by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glutamate-Cysteine Ligase
Share to Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to In Vitro Techniques

Share to Oxidation-Reduction

Share to PTEN Phosphohydrolase

Share to RNA, Small Interfering

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 20637195
DOI: 10.1016/j.febslet.2010.07.006

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Redox regulation of the tumor suppressor PTEN by glutathione.PMID 20637195Read ↗

Role of Glutathione in Cancer Progression and ChemoresistanceSemantic proximity Read ↗

The yeast autophagy protease Atg4 is regulated by thioredoxin.Semantic proximity Read ↗

Tyr740 and Tyr751 residues of platelet-derived growth factor beta receptor are responsible for the redox regulation of phosphatase and tensin homolog in the cells stimulated with platelet-derived growth factor.Semantic proximity Read ↗

Glutathione S-transferase omega suppresses the defective phenotypes caused by PINK1 loss-of-function in Drosophila.Semantic proximity Read ↗

Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae.Semantic proximity Read ↗

Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.Semantic proximity Read ↗

Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient MiceSemantic proximity Read ↗

Differential roles of tau class glutathione S-transferases in oxidative stress.Semantic proximity Read ↗

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.Semantic proximity Read ↗

Hyper-activation of the target of rapamycin (Tor) kinase 1 decreases intracellular glutathione content in Saccharomyces cerevisiae as revealed by LC-MS/MS analysis.Semantic proximity Read ↗

Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL).Semantic proximity Read ↗

Redox status in a model of cancer stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.